Welcome to the laboratory of Dr. Adrian Lee and Dr. Steffi Oesterreich!
The Lee-Oesterreich lab studies the molecular basis of breast cancer development and resistance to therapy, with the goal to improve precision medicine and outcomes for breast cancer patients. We employ a systems biology approach, utilizing a combination of single cell, spatial and bulk sequencing, novel computational biology approaches, and new biological models to identify and validate drivers and therapeutic targets.
Most studies incorporate analysis of human specimens (such as from our Hope for OTHERS post-mortem autopsy program), in collaboration with a large network of clinicians. This includes computational analysis and modeling of large biomedical and genomic datasets including EHR data.
Major focus areas of the Lee-Oesterreich laboratory:
- Mechanisms of resistance to endocrine therapy through the study of estrogen receptor (ESR1) mutations and fusions.
- Understanding breast cancer metastasis through liquid biopsies and precision medicine.
- Study of invasive lobular cancer (ILC), the second most common but understudied histological subtype of breast cancer.
- Development and application of novel computational biology approaches to understand the tumor microenvironment, in particular interaction between tumor and immune cells
- Generation and credentialing of next-generation models of breast cancer
The laboratory has a very strong training environment, with attention to each individuals’ successful career development. One of the top priorities is to maintain a healthy lab environment, ensuring high productivity and rigor.
Since 2022, The Lee-Oesterreich Lab has called “The Assembly” our research home.
