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Our paper about ESR1 mutations and breast cancer metastasis is now published in Cancer Research! 

https://cancerres.aacrjournals.org/content/early/2022/01/25/0008-5472.CAN-21-2576
Zheqi (Vaciry) Li, Ph.D.

This study was led by former graduate student Vaciry Li with great efforts from many intra- and inter-group collaborations. Congratulations to all! 

In this study, we showed that context and allele-dependent transcriptome and cistrome reprogramming in ESR1 mutation cell models, which elicit diverse metastatic phenotypes related to cell-cell adhesion, cell-ECM adhesion and migration driven by increased desmosome/gap junctions, dampened TIMP3-MMP axis and Wnt pathway. Importantly, some of these pathways can pharmacologically targeted and reveals novel therapeutic strategies.  

Our new review is out now in The Lancet Healthy Longevity!

Led by PhD student Neil Carleton and senior authors Adrian Lee, Priscilla McAuliffe, and Steffi Oesterreich, we review key considerations for “right-sizing” therapy options for older women with ER+ breast cancer. With contributions from radiation, pathology, surgical oncology, radiation oncology, and medical oncology from the UPMC / Magee Women’s Hospital breast cancer group, this collaborative effort touches on optimizing quality of life along with new translational studies that may impact future treatment of these patients. 

Check it out at: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00280-4/fulltext.  

Congrats to Neil and the lab on their recent paper studying treatment regimens for elderly breast cancer – out now in JAMA Network Open!

Update (7/16/2021): Check out the 21 news stories written on our recent publication!
https://jamanetwork.altmetric.com/details/103966504/news

Led by Neil Carleton with significant contributions from others in the lab (Osama Shah & Fangyuan (Chelsea) Chen), we studied trends of use of two interventions, sentinel lymph node biopsy (SLNB) and radiation therapy (RT), in elderly women with ER+, clinically node-negative breast cancer. Despite two national guidelines recommending against their use, trends of use by surgical oncologists and radiation oncologists remain quite high. We used propensity score matching to control for confounding and biases in retrospective analysis. Significantly, we found that omitting either SLNB or RT was a feasible approach to care and did not compromise recurrence free survival. Our results bolster the existing clinical guidelines recommending for de-implementation of these interventions.

This was a highly collaborative projects with input from authors in biostatistics, radiation oncology, surgical oncology, medical oncology, and specialists in women’s cancer.

Excitingly, this paper received quite a bit of attention in the media and in the field at large! We were thrilled to see Dr. Lee appear on multiple local TV news stations and Dr. McAuliffe making a number of radio appearances!

Link to paper on journal website: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2778563

Link to Hillman Cancer Center Press Release press release: https://hillmanresearch.upmc.edu/breast-cancer-treatment-study/

Link to Adrian’s KDKA segment: https://pittsburgh.cbslocal.com/video/5495249-upmc-study-not-all-breast-cancer-should-be-treated/

Link to Adrian’s WTAE segment: https://www.wtae.com/article/sometimes-less-is-better-study-looks-at-treatment-of-breast-cancer-patients-over-70/36159559

Ashuvinee Elangovan wins the GRC and BGSA travel awards!

Congrats to Ashuvinee Elangovan for winning the GRC and BGSA travel awards!

Ashuvinee Elangovan
Graduate Student

Ashuvinee Elangovan, a 2nd year graduate student in the lab won travel awards from the Gordon Research (GRC) Conferences and the Biomedical Graduate Student Association (BGSA) for the upcoming Gordon conference on IGF and Insulin System in Physiology and Disease in Ventura, CA.

Congrats to Dr. Tasdemir and colleagues on their new BioRxiv pre-print!

Congratulations to Nilgun Tasdemir on her new publication!

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast Cancer – biorxiv.org

Abstract. BACKGROUND: Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer with distinct molecular and clinical features from the more common subtype invasive lobular carcinoma (IDC).www.biorxiv.org

New Publication! “Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors”

Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors

We provide evidence that loss of E-cadherin hyperactivates the IGF1R pathway and increases sensitivity to IGF1R/InsR targeted therapy, thus identifying the IGF1R pathway as a potential novel target in E-cadherin–deficient breast cancers such as invasive lobular cancer.