We provide evidence that loss of E-cadherin hyperactivates the IGF1R pathway and increases sensitivity to IGF1R/InsR targeted therapy, thus identifying the IGF1R pathway as a potential novel target in E-cadherin–deficient breast cancers such as invasive lobular cancer.
Congratulation Dr. Nilgun Tasdemir and coauthors for their new publication generating an invaluable resource for lobular breast cancer research. Comprehensive characterization of ILC models.
Our latest paper focused on lobular breast cancer is now available. Role for SREBP1 and other regulators of fatty acid and cholesterol synthesis in invasive lobular breast cancer.
Small. 2018 Aug;14(32):e1801131. doi: 10.1002/smll.201801131. Epub 2018 Jul 3.
Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation.
Wu M1, Huang PH1, Zhang R2, Mao Z2, Chen C1, Kemeny G3, Li P4, Lee AV5, Gyanchandani R5, Armstrong AJ3, Dao M6, Suresh S7, Huang TJ1.
Abstract
The study of circulating tumor cells (CTCs) offers pathways to develop new diagnostic and prognostic biomarkers that benefit cancer treatments. In order to fully exploit and interpret the information provided by CTCs, the development of a platform is reported that integrates acoustics and microfluidics to isolate rare CTCs from peripheral blood in high throughput while preserving their structural, biological, and functional integrity. Cancer cells are first isolated from leukocytes with a throughput of 7.5 mL h-1 , achieving a recovery rate of at least 86% while maintaining the cells’ ability to proliferate. High-throughput acoustic separation enables statistical analysis of isolated CTCs from prostate cancer patients to be performed to determine their size distribution and phenotypic heterogeneity for a range of biomarkers, including the visualization of CTCs with a loss of expression for the prostate specific membrane antigen. The method also enables the isolation of even rarer, but clinically important, CTC clusters.
Congratulations to Amir, Vaciry, and others on their publication on characterization of ER mutations in breast cancer cells (Bahreini, Li, et al, BCR 2017). Well done!
AACR journal Clinical Cancer Research recently released a paper titled “Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens” in January this year. Our previous lab member Dr. Courtney Andersen was the first author of this paper.
