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specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities. Nat Commun. 2022 Jan 26;13(1):514. doi: 10.1038/s41467-022-27987-5. PMID: 35082299; PMCID: PMC8791982.

Carleton N, Nasrazadani A, Gade K, Beriwal S, Barry PN, Brufsky AM, Bhargava R, Berg WA, Zuley ML, van Londen GJ, Marroquin OC, Thull DL, Mai PL, Diego EJ, Lotze MT, Oesterreich S, McAuliffe PF, Lee AV. Personalising therapy for early-stage oestrogen receptor-positive breast cancer in older women. Lancet Healthy Longev. 2022 Jan;3(1):e54-e66. doi: 10.1016/s2666-7568(21)00280-4. Epub 2022 Jan 5. PMID: 35047868; PMCID: PMC8765742.

Manzo J, Puhalla S, Pahuja S, Ding F, Lin Y, Appleman L, Tawbi H, Stoller R, Lee JJ, Diergaarde B, Kiesel BF, Yu J, Tan AR, Belani CP, Chew H, Garcia AA, Morgan RJ, Wahner Hendrickson AE, Visscher DW, Hurley RM, Kaufmann SH, Swisher EM, Oesterreich S, Katz T, Ji J, Zhang Y, Parchment RE, Chen A, Duan W, Giranda V, Shepherd SP, Ivy SP, Chu E, Beumer JH; ETCTN-8282 study team. A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT-888) in patients with BRCA1- or BRCA2-mutated cancer or platinum-refractory ovarian or triple-negative breast cancer. Cancer Chemother Pharmacol. 2022 Apr 18. doi: 10.1007/s00280-022-04430-6. Epub ahead of print. PMID: 35435472.

Guillen KP, Fujita M, Butterfield AJ, Scherer SD, Bailey MH, Chu Z, DeRose YS, Zhao L, Cortes-Sanchez E, Yang CH, Toner J, Wang G, Qiao Y, Huang X, Greenland JA, Vahrenkamp JM, Lum DH, Factor RE, Nelson EW, Matsen CB, Poretta JM, Rosenthal R, Beck AC, Bus SS, Vaklavas C, Ward JH, Jensen RL, Jones KB, Li Z, Oesterreich S, Dobrolecki LE, Pathi SS, Woo XY, Berrett KC, Wadsworth ME, Chuang JH, Lewis MT, Marth GT, Gertz J, Varley KE, Welm BE, Welm AL. A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology. Nat Cancer. 2022 Feb;3(2):232-250. doi: 10.1038/s43018-022-00337-6. Epub 2022 Feb 24. PMID: 35221336; PMCID: PMC8882468.

Li Z, Wu Y, Yates ME, Tasdemir N, Bahreini A, Chen J, Levine KM, Priedigkeit NM, Nasrazadani A, Ali S, Buluwela L, Arnesen S, Gertz J, Richer JK, Troness B, El-Ashry D, Zhang Q, Gerratana L, Zhang Y, Cristofanilli M, Montanez MA, Sundd P, Wallace CT, Watkins SC, Fumagalli C, Guerini-Rocco E, Zhu L, Tseng GC, Wagle N, Carroll JS, Jank P, Denkert C, Karsten MM, Blohmer JU, Park BH, Lucas PC, Atkinson JM, Lee AV, Oesterreich S. Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis. Cancer Res. 2022 Jan 25:canres.CAN-21-2576-E.2021. doi: 10.1158/0008-5472.CAN-21-2576. Epub ahead of print. PMID: 35078818.

Rosenzweig M, Miller LA, Lee AV, Oesterreich S, Trejo Bittar HE, Atkinson JM, Welsh A. The Development and Implementation of an Autopsy/ Tissue Donation for Breast Cancer Research. New Bioeth. 2021 Dec;27(4):349-361. doi:
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Sflomos G, Schipper K, Koorman T, Fitzpatrick A, Oesterreich S, Lee AV, Jonkers J, Brunton VG, Christgen M, Isacke C, Derksen PWB, Brisken C. Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions. Cancers (Basel). 2021 Oct 27;13(21):5396. doi: 10.3390/cancers13215396. PMID: 34771558; PMCID: PMC8582475.

Lee JL, Ekambaram P, Carleton NM, Hu D, Klei LR, Cai Z, Myers MI, Hubel NE, Covic L, Agnihotri S, Krappmann D, Bornancin F, Lee AV, Oesterreich S, McAllister-Lucas LM, Lucas PC. MALT1 Is a Targetable Driver of Epithelial-to-
Mesenchymal Transition in Claudin-Low, Triple-Negative Breast Cancer. Mol Cancer Res. 2021 Nov 9. doi: 10.1158/1541-7786.MCR-21-0208. Epub ahead of print. PMID: 34753803.

Scherer SD, Riggio AI, Haroun F, DeRose YS, Ekiz HA, Fujita M, Toner J, Zhao L, Li Z, Oesterreich S, Samatar AA, Welm AL. An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer. Breast Cancer Res. 2021 Oct 30;23(1):100. doi: 10.1186/s13058-021-01476-x. PMID: 34717714; PMCID: PMC8556932.

Gou X, Anurag M, Lei JT, Kim BJ, Singh P, Seker S, Fandino D, Han A, Rehman S, Hu J, Korchina V, Doddapaneni H, Dobrolecki LE, Mitsiades N, Lewis MT, Welm AL, Li S, Lee AV, Robinson DR, Foulds CE, Ellis MJ. Transcriptional
Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer. Cancer Res. 2021 Dec 15;81(24):6259-6272. doi: 10.1158/0008-5472.CAN-21-1256. Epub 2021 Oct 28. PMID:
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Mohammad Mirzaei N, Su S, Sofia D, Hegarty M, Abdel-Rahman MH, Asadpoure A, Cebulla CM, Chang YH, Hao W, Jackson PR, Lee AV, Stover DG, Tatarova Z, Zervantonakis IK, Shahriyari L. A Mathematical Model of Breast Tumor Progression Based on Immune Infiltration. J Pers Med. 2021 Oct 15;11(10):1031. doi: 10.3390/jpm11101031. PMID: 34683171; PMCID: PMC8540934.

Nunes R, Sella T, Treuner K, Atkinson JM, Wong J, Zhang Y, Exman P, Dabbs D, Richardson AL, Schnabel CA, Sgroi DC, Oesterreich S, Cimino-Mathews A, Metzger O. Prognostic utility of Breast Cancer Index to stratify distant recurrence risk in invasive lobular carcinoma. Clin Cancer Res. 2021 Aug 10:clincanres.0733.2021. doi: 10.1158/1078-0432.CCR-21-0733. Epub ahead of print. PMID: 34376532.

Watters RJ, Verdelis K, Lucas PC, Jiang S, Chen Y, Lu F, Martin BM, Lukashova L, Pecar G, Morales-Restrepo A, Hankins M, Zhu L, Mittwede P, Hartmaier RJ, Alexander PG, Tseng GC, Weiss KR, Galson DL, Lee AV, Lee B, Oesterreich S. A
Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis. Endocrinology. 2021 Aug 1;162(8):bqab094. doi: 10.1210/endocr/bqab094. PMID: 33963375; PMCID:
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Erdem C, Lee AV, Taylor DL, Lezon TR. Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells. PLoS Comput Biol. 2021 Jun 30;17(6):e1009125. doi: 10.1371/journal.pcbi.1009125. PMID: 34191793; PMCID: PMC8277016.

Pate L, Desmedt C, Metzger O, Burgess Hutcheson L, Turner C, Freeney S, Oesterreich S. How Researchers, Clinicians and Patient Advocates Can Accelerate Lobular Breast Cancer Research. Cancers (Basel). 2021 Jun 22;13(13):3094. doi:
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Sannino S, Yates ME, Schurdak ME, Oesterreich S, Lee AV, Wipf P, Brodsky JL. Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised. Elife. 2021 Jun 28;10:e64977. doi:
10.7554/eLife.64977. PMID:https://pubmed.ncbi.nlm.nih.gov/34180400/ 34180400; PMCID: PMC8275131.

Hankins ML, Smith CN, Hersh B, Heim T, Belayneh R, Dooley S, Lee AV, Oesterreich S, Lucas PC, Puhalla SL, Weiss KR, Watters RJ. Prognostic factors and survival of patients undergoing surgical intervention for breast cancer bone
metastases. J Bone Oncol. 2021 May 3;29:100363. doi: 10.1016/j.jbo.2021.100363. PMID: 34040953; PMCID: PMC8143999.

Carleton N, Zou J, Fang Y, Koscumb SE, Shah OS, Chen F, Beriwal S, Diego EJ, Brufsky AM, Oesterreich S, Shapiro SD, Ferris R, Emens LA, Tseng G, Marroquin OC, Lee AV, McAuliffe PF. Outcomes After Sentinel Lymph Node Biopsy and Radiotherapy in Older Women With Early-Stage, Estrogen Receptor-Positive Breast Cancer. JAMA Netw Open. 2021 Apr 1;4(4):e216322. doi: 10.1001/jamanetworkopen.2021.6322. PMID: 33856473.

Liu T, Hooda J, Atkinson JM, Whiteside TL, Oesterreich S, Lee AV. Exosomes in breast cancer – Mechanisms of Action and Clinical Potential. Mol Cancer Res. 2021 Feb 24:molcanres.0952.2020. doi: 10.1158/1541-7786.MCR-20-0952. Epub ahead of print. PMID: 33627501.

Varešlija D, Ward E, Purcell SP, Cosgrove NS, Cocchiglia S, O’Halloran PJ, Charmsaz S, Bane FT, Brett FM, Farrell M, Cryan J, Beausang A, Hudson L, Turnbul AK, Dixon JM, Hill ADK, Priedigkeit N, Oesterreich S, Lee AV, Sims AH, Redmond AM, Carroll JS, Young LS. Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype. Oncogene. 2021 Feb;40(7):1318-1331. doi: 10.1038/s41388-020-01606-3. Epub 2021 Jan 8. PMID: 33420368; PMCID: PMC7892341.

Priedigkeit N, Ding K, Horne W, Kolls JK, Du T, Lucas PC, Blohmer JU, Denkert C, Machleidt A, Ingold-Heppner B, Oesterreich S, Lee AV. Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences. Breast Cancer Res. 2021 Jan 6;23(1):1. doi: 10.1186/s13058-020-01379-3. PMID: 33407744; PMCID: PMC7788918.

Arnesen S, Blanchard Z, Williams MM, Berrett KC, Li Z, Oesterreich S, Richer JK, Gertz J. Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects. Cancer Res. 2021 Feb 1;81(3):539-551. doi: 10.1158/0008-5472.CAN-20-1171. Epub 2020 Nov 12. PMID: 33184109; PMCID: PMC7854489.

Williams MM, Spoelstra NS, Arnesen S, O’Neill KI, Christenson JL, Reese J, Torkko KC, Goodspeed A, Rosas E, Hanamura T, Sams SB, Li Z, Oesterreich S, Riggins RB, Jacobsen BM, Elias A, Gertz J, Richer JK. Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of <i>ESR1</i>-Mutant Breast Cancer. Cancer Res. 2021 Feb 1;81(3):732-746. doi: 10.1158/0008-5472.CAN-20-1200. Epub 2020 Nov 12. PMID: 33184106; PMCID: PMC7854521.

Chen F, Ding K, Priedigkeit N, Elangovan A, Levine KM, Carleton N, Savariau L, Atkinson JM, Oesterreich S, Lee AV. Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells. Cancer Res. 2021 Jan 15;81(2):268-281. doi: 10.1158/0008-5472.CAN-20-0696. Epub 2020 Nov 4. PMID: 33148662; PMCID: PMC7856056.

Charmsaz S, Doherty B, Cocchiglia S, Varešlija D, Marino A, Cosgrove N, Marques R, Priedigkeit N, Purcell S, Bane F, Bolger J, Byrne C, O’Halloran PJ, Brett F, Sheehan K, Brennan K, Hopkins AM, Keelan S, Jagust P, Madden S, Martinelli C, Battaglini M, Oesterreich S, Lee AV, Ciofani G, Hill ADK, Young LS. ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis. BMC Med. 2020 Nov 19;18(1):349. doi: 10.1186/s12916-020-01806-4. PMID: 33208158; PMCID: PMC7677775.

Tao Y, Lei H, Lee AV, Ma J, Schwartz R. Neural Network Deconvolution Method for Resolving Pathway-Level Progression of Tumor Clonal Expression Programs With Application to Breast Cancer Brain Metastases. Front Physiol. 2020 Sep 4;11:1055. doi: 10.3389/fphys.2020.01055. PMID: 33013452; PMCID: PMC7499245.

Shackleford MT, Rao DM, Bordeaux EK, Hicks HM, Towers CG, Sottnik JL, Oesterreich S, Sikora MJ. Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4. Cancers (Basel). 2020 Oct 12;12(10):2931. doi: 10.3390/cancers12102931. PMID: 33053661; PMCID: PMC7650584.

Shah OS, Soran A, Sahin M, Knapick BA, Ugras S, Celik E, Lucas PC, Lee AV. Identifying Genomic Alterations in Patients With Stage IV Breast Cancer Using MammaSeq: An International Collaborative Study. Clin Breast Cancer. 2020 Aug 20:S1526-8209(20)30213-5. doi: 10.1016/j.clbc.2020.08.009. Epub ahead of print. PMID: 33191115.

Kurozumi S, Alsaleem M, Monteiro CJ, Bhardwaj K, Joosten SEP, Fujii T, Shirabe K, Green AR, Ellis IO, Rakha EA, Mongan NP, Heery DM, Zwart W, Oesterreich S, Johnston SJ. Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets. Breast Cancer Res. 2020 Aug 11;22(1):85. doi: 10.1186/s13058-020-01324-4. PMID: 32782013; PMCID: PMC7422515.

Palliyaguru DL, Yang L, Chartoumpekis DV, Wendell SG, Fazzari M, Skoko JJ, Liao Y, Oesterreich S, Michalopoulos GK, Kensler TW. Sulforaphane Diminishes the Formation of Mammary Tumors in Rats Exposed to 17β-Estradiol. Nutrients. 2020 Jul 30;12(8):2282. doi: 10.3390/nu12082282. PMID: 32751496; PMCID: PMC7468750.

Tao Y, Lei H, Fu X, Lee AV, Ma J, Schwartz R. Robust and accurate deconvolution of tumor populations uncovers evolutionary mechanisms of breast cancer metastasis. Bioinformatics. 2020 Jul 1;36(Supplement_1):i407-i416. doi: 10.1093/bioinformatics/btaa396. PMID: 32657393; PMCID: PMC7355293.

Tasdemir N, Ding K, Savariau L, Levine KM, Du T, Elangovan A, Bossart EA, Lee AV, Davidson NE, Oesterreich S. Proteomic and transcriptomic profiling identifies mediators of anchorage-independent growth and roles of inhibitor of differentiation proteins in invasive lobular carcinoma. Sci Rep. 2020 Jul 13;10(1):11487. doi: 10.1038/s41598-020-68141-9. PMID: 32661241; PMCID: PMC7359337.

Zhao Y, Wu D, Jiang D, Zhang X, Wu T, Cui J, Qian M, Zhao J, Oesterreich S, Sun W, Finkel T, Li G. A sequential methodology for the rapid identification and characterization of breast cancer-associated functional SNPs. Nat Commun. 2020 Jul 3;11(1):3340. doi: 10.1038/s41467-020-17159-8. PMID: 32620845; PMCID: PMC7334201.

Sreekumar S, Levine KM, Sikora MJ, Chen J, Tasdemir N, Carter D, Dabbs DJ, Meier C, Basudan A, Boone D, McAuliffe PF, Jankowitz RC, Lee AV, Atkinson JM, Oesterreich S. Differential regulation and targeting of estrogen receptor α turnover in invasive lobular breast carcinoma. Endocrinology. 2020 Jul 1:bqaa109. doi: 10.1210/endocr/bqaa109. Epub ahead of print. PMID: 32609836.

Farabaugh SM, Litzenburger BC, Elangovan A, Pecar G, Walheim L, Atkinson JM, Lee AV. IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis. Dev Biol. 2020 Jul 1;463(1):77-87. doi: 10.1016/j.ydbio.2020.04.007. Epub 2020 May 4. PMID: 32376245; PMCID: PMC7297516.

Andreano KJ, Baker JG, Park S, Safi R, Artham S, Oesterreich S, Jeselsohn R, Brown M, Sammons S, Wardell SE, Chang CY, Norris JD, McDonnell DP. The Dysregulated Pharmacology of Clinically Relevant <i>ESR1</i> Mutants is Normalized by Ligand-activated WT Receptor. Mol Cancer Ther. 2020 Jul;19(7):1395-1405. doi: 10.1158/1535-7163.MCT-19-1148. Epub 2020 May 7. PMID: 32381587; PMCID: PMC7335351.

Blohmer M, Zhu L, Atkinson JM, Beriwal S, Rodríguez-López JL, Rosenzweig M, Brufsky AM, Tseng G, Lucas PC, Lee AV, Oesterreich S, Jankowitz RC. Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology. Breast Cancer Res. 2020 Jun 26;22(1):70. doi: 10.1186/s13058-020-01309-3. PMID: 32586354; PMCID: PMC7318761.

Levine KM, Ding K, Chen L, Oesterreich S. FGFR4: A promising therapeutic target for breast cancer and other solid tumors. Pharmacol Ther. 2020 May 31:107590. doi: 10.1016/j.pharmthera.2020.107590. Epub ahead of print. PMID: 32492514.

Boone DN, Warburton A, Som S, Lee AV. SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation. Sci Rep. 2020 May 22;10(1):8583. doi: 10.1038/s41598-020-65109-7. PMID: 32444795; PMCID: PMC7244715.

Sokol ES, Pavlick D, Khiabanian H, Frampton GM, Ross JS, Gregg JP, Lara PN, Oesterreich S, Agarwal N, Necchi A, Miller VA, Alexander B, Ali SM, Ganesan S, Chung JH. Pan-Cancer Analysis of <i>BRCA1</i> and <i>BRCA2</i> Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity. JCO Precis Oncol. 2020;4:442-465. doi: 10.1200/po.19.00345. Epub 2020 Apr 30. PMID: 32903788; PMCID: PMC7446440.

Zhu L, Narloch JL, Onkar S, Joy M, Broadwater G, Luedke C, Hall A, Kim R, Pogue-Geile K, Sammons S, Nayyar N, Chukwueke U, Brastianos PK, Anders CK, Soloff AC, Vignali DAA, Tseng GC, Emens LA, Lucas PC, Blackwell KL, Oesterreich S, Lee AV. Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors. J Immunother Cancer. 2019 Oct 18;7(1):265. doi: 10.1186/s40425-019-0755-1. Erratum in: J Immunother Cancer. 2020 Apr;8(1):. PubMed PMID: 31627744; PubMed Central PMCID: PMC6798422.

Cillo AR, Kürten CHL, Tabib T, Qi Z, Onkar S, Wang T, Liu A, Duvvuri U, Kim S, Soose RJ, Oesterreich S, Chen W, Lafyatis R, Bruno TC, Ferris RL, Vignali DAA. Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer. Immunity. 2020 Jan 14;52(1):183-199.e9. doi: 10.1016/j.immuni.2019.11.014. Epub 2020 Jan 7. PubMed PMID: 31924475.

Cai C, Cooper GF, Lu KN, Ma X, Xu S, Zhao Z, Chen X, Xue Y, Lee AV, Clark N, Chen V, Lu S, Chen L, Yu L, Hochheiser HS, Jiang X, Wang QJ, Lu X. Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference. PLoS Comput Biol. 2019 Jul 5;15(7):e1007088. doi: 10.1371/journal.pcbi.1007088. eCollection 2019 Jul. PubMed PMID: 31276486.

Levine KM, Priedigkeit N, Basudan A, Tasdemir N, Sikora MJ, Sokol ES, Hartmaier RJ, Ding K, Ahmad NZ, Watters RJ, Weiss KR, Blohmer JU, Denkert C, Machleidt A, Karsten MM, Boisen MM, Elishaev E, Lucas PC, Lee AV, Oesterreich S. FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype. NPJ Breast Cancer. 2019 Jun 27;5:19. doi: 10.1038/s41523-019-0114-x. eCollection 2019. PubMed PMID: 31263748; PubMed
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Cao L, Basudan A, Sikora MJ, Bahreini A, Tasdemir N, Levine KM, Jankowitz RC, McAuliffe PF, Dabbs D, Haupt S, Haupt Y, Lucas PC, Lee AV, Oesterreich S, Atkinson JM. Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma. Cancer Lett. 2019 Jun 20;461:21-30. doi: 10.1016/j.canlet.2019.06.011. [Epub ahead of print] PubMed PMID: 31229512.

Chattopadhyay A, Iwema CL, Epstein BA, Lee AV, Levine AS. Molecular Biology Information Service: an innovative medical library-based bioinformatics support service for biomedical researchers. Brief Bioinform. 2019 Apr 5. pii: bbz035. doi: 10.1093/bib/bbz035. [Epub ahead of print] PubMed PMID: 30949666.

Bossart EA, Tasdemir N, Sikora MJ, Bahreini A, Levine KM, Chen J, Basudan A, Jacobsen BM, Burns TF, Oesterreich S. SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma. Breast Cancer Res Treat. 2019 Jun;175(2):327-337. doi: 10.1007/s10549-019-05161-8. Epub 2019 Feb 23.
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Rieunier G, Wu X, Macaulay VM, Lee AV, Weyer-Czernilofsky U, Bogenrieder T. Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis. Clin Cancer Res. 2019 Feb 11. pii: clincanres.2697.2018. doi: 10.1158/1078-0432.CCR-18-2697. [Epub ahead of print] PubMed PMID: 30745299.

Ruffalo M, Thomas R, Chen J, Lee AV, Oesterreich S, Bar-Joseph Z.
Network-guided prediction of aromatase inhibitor response in breast cancer. PLoS Comput Biol. 2019 Feb 11;15(2):e1006730. doi: 10.1371/journal.pcbi.1006730. [Epub ahead of print] PubMed PMID: 30742607.

Smith NG, Gyanchandani R, Shah OS, Gurda GT, Lucas PC, Hartmaier RJ, Brufsky AM, Puhalla S, Bahreini A, Kota K, Wald AI, Nikiforov YE, Nikiforova MN, Oesterreich S, Lee AV. Targeted mutation detection in breast cancer using MammaSeq™. Breast Cancer Res. 2019 Feb 8;21(1):22. doi: 10.1186/s13058-019-1102-7. PubMed PMID: 30736836; PubMed Central PMCID: PMC6368740.

Basudan A, Priedigkeit N, Hartmaier RJ, Sokol ES, Bahreini A, Watters RJ, Boisen MM, Bhargava R, Weiss KR, Karsten MM, Denkert C, Blohmer JU, Leone JP, Hamilton RL, Brufsky AM, Elishaev E, Lucas PC, Lee AV, Oesterreich S. Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer. Mol Cancer Res. 2019 Feb;17(2):457-468. doi: 10.1158/1541-7786.MCR-18-0946. Epub 2018 Oct 24. PubMed PMID: 30355675; PubMed Central PMCID: PMC6359977.

Sokol ES, Feng YX, Jin DX, Basudan A, Lee AV, Atkinson JM, Chen J, Stephens PJ, Frampton GM, Gupta PB, Ross JS, Chung JH, Oesterreich S, Ali SM, Hartmaier RJ. Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer. Ann Oncol. 2019 Jan 1;30(1):115-123. doi: 10.1093/annonc/mdy497. PubMed PMID: 30423024; PubMed Central PMCID: PMC6336006.

Qin Y, Vasilatos SN, Chen L, Wu H, Cao Z, Fu Y, Huang M, Vlad AM, Lu B, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Oncogene. 2019 Jan;38(3):390-405. doi: 10.1038/s41388-018-0451-5. Epub 2018 Aug 15. PubMed PMID: 30111819; PubMed Central PMCID: PMC6336685.

Linkov F, Silverstein JC, Davis M, Crocker B, Hao D, Schneider A, Schwenk M,Winters S, Zelnis J, Lee AV, Becich MJ. Integration of Cancer Registry Data into the Text Information Extraction System: Leveraging the Structured Data Import Tool. J Pathol Inform. 2018 Dec 24;9:47. doi: 10.4103/jpi.jpi_38_18. eCollection 2018. PubMed PMID: 30662793; PubMed Central PMCID: PMC6319041.

Gyanchandani R, Kvam E, Heller R, Finehout E, Smith N, Kota K, Nelson JR, Griffin W, Puhalla S, Brufsky AM, Davidson NE, Lee AV. Whole genome amplification of cell-free DNA enables detection of circulating tumor DNA mutations from fingerstick capillary blood. Sci Rep. 2018 Nov 23;8(1):17313. doi: 10.1038/s41598-018-35470-9. PubMed PMID: 30470782; PubMed Central PMCID: PMC6251935.

Ma T, Huo Z, Kuo A, Zhu L, Fang Z, Zeng X, Lin CW, Liu S, Wang L, Liu P, Rahman T, Chang LC, Kim S, Li J, Park Y, Song C, Oesterreich S, Sibille E, Tseng GC. MetaOmics: Analysis Pipeline and Browser-based Software Suite for Transcriptomic Meta-Analysis. Bioinformatics. 2018 Oct 10. doi: 10.1093/bioinformatics/bty825. [Epub ahead of print] PubMed PMID: 30304367.

Nagle AM, Levine KM, Tasdemir N, Scott JA, Burlbaugh K, Kehm J, Katz TA, Boone DN, Jacobsen BM, Atkinson JM, Oesterreich S, Lee AV. Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors. Clin Cancer Res. 2018 Jun 25. doi: 10.1158/1078-0432.CCR-18-0279. [Epub ahead of print]

Tasdemir N, Bossart EA, Li Z, Zhu L, Sikora MJ, Levine KM, Jacobsen BM, Tseng GC, Davidson NE, and Oesterreich S. Comprehensive phenotypic characterization of human invasive lobular carcinoma cell lines in 2D and 3D cultures. Cancer Res September 18 2018 DOI: 10.1158/0008-5472.CAN-18-1416

Varešlija D, Priedigkeit N, Fagan A, Purcell S, Cosgrove N, O’Halloran PJ, Ward E, Cocchiglia S, Hartmaier R, Castro CA, Zhu L, Tseng GC, Lucas PC, Puhalla SL, Brufsky AM, Hamilton RL, Mathew A, Leone JP, Basudan A, Hudson L, Dwyer R,s Das S, O’Connor DP, Buckley PG, Farrell M, Hill ADK, Oesterreich S, Lee AV, Young LS. Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets. J Natl Cancer Inst. 2018 Jun 28. doi: 10.1093/jnci/djy110. [Epub ahead of print] PubMed PMID: 29961873.

Nagle AM, Levine KM, Tasdemir N, Scott JA, Burlbaugh K, Kehm J, Katz TA, Boone DN, Jacobsen BM, Atkinson JM, Oesterreich S, Lee AV. Loss of E-cadherin Enhances  IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors. Clin Cancer Res. 2018 Jun 25. doi: 10.1158/1078-0432.CCR-18-0279. [Epub ahead of print] PubMed PMID: 29941485.

Nasrazadani A, Thomas RA, Oesterreich S, Lee AV. Precision Medicine in Hormone Receptor-Positive Breast Cancer. Front Oncol. 2018 May 4;8:144. doi: 10.3389/fonc.2018.00144. eCollection 2018. Review. PubMed PMID: 29780747; PubMed Central PMCID: PMC5945817.

Du T, Zhu L, Levine KM, Tasdemir N, Lee AV, Vignali DAA, Houten BV, Tseng GC, Oesterreich S. Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism. Sci Rep. 2018 May 8;8(1):7205. doi: 10.1038/s41598-018-25357-0. PubMed PMID: 29739984; PubMed Central PMCID: PMC5940770.

Hartmaier RJ, Trabucco SE, Priedigkeit N, Chung JH, Parachoniak CA, Vanden Borre P, Morley S, Rosenzweig M, Gay LM, Goldberg ME, Suh J, Ali SM, Ross J, Leyland-Jones B, Young B, Williams C, Park B, Tsai M, Haley B, PegueroJ, Callahan RD, Sachelarie I, Cho J, Atkinson JM, Bahreini A, Nagle AM, Puhalla SL, Watters RJ, Erdogan-Yildirim Z, Cao L, Oesterreich S, Mathew A, Lucas PC, Davidson NE, Brufsky AM, Frampton GM, Stephens PJ, Chmielecki J, Lee AV. Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer. Ann Oncol. 2018 Apr 1;29(4):872-880. doi: 10.1093/annonc/mdy025.  PubMed PMID: 29360925; PubMed Central PMCID: PMC5913625.

Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM. Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes. Oncology. 2018;94(3):176-189. doi:10.1159/000485510. Epub 2018 Jan 6. PubMed PMID: 29306943; PubMed Central PMCID: PMC5828968.

Ekambaram P, Lee JL, Hubel NE, Hu D, Yerneni S, Campbell PG, Pollock N, Klei LR, Concel VJ, Delekta PC, Chinnaiyan AM, Tomlins SA, Rhodes DR, Priedigkeit N, Lee AV, Oesterreich S, McAllister-Lucas LM, Lucas PC. The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II  Receptor-Positive Breast Cancer. Cancer Res. 2018 Mar 1;78(5):1225-1240. doi: 10.1158/0008-5472.CAN-17-1089. Epub 2017 Dec 19. PubMed PMID: 29259013.

Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018 Jan 1;159(1):285-296. doi: 10.1210/en.2017-00693. PubMed PMID: 29029116; PubMed Central PMCID: PMC5761602.

Hopkins BL, Nadler M, Skoko JJ, Bertomeu T, Pelosi A, Shafaei PM, Levine K, Schempf A, Pennarun B, Yang B, Datta D, Bucur O, Ndebele K, Oesterreich S, Yang D, Giulia Rizzo M, Khosravi-Far R, Neumann CA. A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7. Antioxid Redox Signal. 2018 Jan 1;28(1):62-77. doi: 10.1089/ars.2016.6871. Epub 2017 May 1. PubMed PMID: 28398822; PubMed Central PMCID: PMC5695745.

Hertz DL, Kidwell KM, Hilsenbeck SG, Oesterreich S, Osborne CK, Philips S, Chenault C, Hartmaier RJ, Skaar TC, Sikora MJ, Rae JM. CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study. Breast Cancer Res Treat. 2017 Nov;166(1):277-287. doi: 10.1007/s10549-017-4400-8. Epub 2017 Jul 20. PubMed PMID: 28730340; PubMed Central PMCID: PMC6028015.

Spagnolo DM, Al-Kofahi Y, Zhu P, Lezon TR, Gough A, Stern AM, Lee AV, Ginty F, Sarachan B, Taylor DL, Chennubhotla SC. Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images. Cancer Res. 2017 Nov 1;77(21):e71-e74. doi: 10.1158/0008-5472.CAN-17-0676. PubMed PMID: 29092944; PubMed Central PMCID: PMC5683175.

Zhao Y, Laws MJ, Guillen VS, Ziegler Y, Min J, Sharma A, Kim SH, Chu D, Park BH, Oesterreich S, Mao C, Shapiro DJ, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS. Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Res. 2017 Oct 15;77(20):5602-5613. doi: 10.1158/0008-5472.CAN-17-1265. Epub 2017 Sep 13. PubMed PMID: 28904064; PubMed Central PMCID: PMC5645250.

Priedigkeit N, Watters RJ, Lucas PC, Basudan A, Bhargava R, Horne W, Kolls JK, Fang Z, Rosenzweig MQ, Brufsky AM, Weiss KR, Oesterreich S, Lee AV. Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases. JCI Insight. 2017 Sep 7;2(17). pii: 95703. doi: 10.1172/jci.insight.95703. [Epub ahead of print] PubMed PMID: 28878133; PubMed Central PMCID: PMC5621874.

Kota K, Brufsky A, Oesterreich S, Lee A. Estradiol as a Targeted, Late-Line Therapy in Metastatic Breast Cancer with Estrogen Receptor Amplification. Cureus. 2017 Jul 6;9(7):e1434. doi: 10.7759/cureus.1434. PubMed PMID: 28924522; PubMed Central PMCID: PMC5587405.

Andersen CL, Sikora MJ, Boisen MM, Ma T, Christie A, Tseng G, Park Y, Luthra S, Chandran U, Haluska P, Mantia-Smaldone GM, Odunsi K, McLean K, Lee AV, Elishaev E, Edwards RP, Oesterreich S. Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens. Clin Cancer Res. 2017 Jul 15;23(14):3802-3812. doi: 10.1158/1078-0432.CCR-16-1501. Epub 2017 Jan 10. PubMed PMID: 28073843; PubMed Central PMCID: PMC5503796.

Gurda GT, Ambros T, Nikiforova MN, Nikiforov YE, Lucas PC, Dabbs DJ, Lee AV, Brufsky AM, Puhalla SL, Bhargava R. Characterizing Molecular Variants and Clinical Utilization of Next-generation Sequencing in Advanced Breast Cancer. Appl Immunohistochem Mol Morphol. 2017 Jul;25(6):392-398. doi: 10.1097/PAI.0000000000000322. PubMed PMID: 26862949.

Ma T, Liang F, Oesterreich S, Tseng GC. A Joint Bayesian Model for Integrating Microarray and RNA Sequencing Transcriptomic Data. J Comput Biol. 2017 Jul;24(7):647-662. doi: 10.1089/cmb.2017.0056. Epub 2017 May 25. PubMed PMID: 28541721; PubMed Central PMCID: PMC5510692.

Watters RJ, Hartmaier RJ, Osmanbeyoglu HU, Gillihan RM, Rae JM, Liao L, Chen K, Li W, Lu X, Oesterreich S. Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen. Mol Cell Endocrinol. 2017 Jun 15;448:21-27. doi: 10.1016/j.mce.2017.03.005. Epub 2017 Mar 7. PubMed PMID: 28286232.

Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S. Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 2017 May 23;19(1):60. doi: 10.1186/s13058-017-0851-4. PubMed PMID: 28535794; PubMed Central PMCID: PMC5442865.

Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV. Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. JAMA Oncol. 2017 May 1;3(5):666-671. doi: 10.1001/jamaoncol.2016.5630. PubMed PMID: 27926948; PubMed Central PMCID: PMC5508875.

Zhu L, Ding Y, Chen CY, Wang L, Huo Z, Kim S, Sotiriou C, Oesterreich S, Tseng GC. MetaDCN: meta-analysis framework for differential co-expression network detection with an application in breast cancer. Bioinformatics. 2017 Apr 15;33(8):1121-1129. doi: 10.1093/bioinformatics/btw788. PubMed PMID: 28031185; PubMed Central PMCID: PMC6041767.

Jankowitz RC, Oesterreich S, Lee AV, Davidson NE. New Strategies in Metastatic Hormone Receptor-Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies. Clin Cancer Res. 2017 Mar 1;23(5):1126-1131. doi: 10.1158/1078-0432.CCR-16-0591. Epub 2016 Dec 15. PubMed PMID: 27979914; PubMed Central PMCID: PMC5350010.

Bahreini A, Levine K, Santana-Santos L, Benos PV, Wang P, Andersen C, Oesterreich S, Lee AV. Non-coding single nucleotide variants affecting estrogen receptor binding and activity. Genome Med. 2016 Dec 13;8(1):128. PubMed PMID: 27964748; PubMed Central PMCID: PMC5154163.

Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X. Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. Cancer Res. 2016 Dec 1;76(23):6785-6794. Epub 2016 Oct 10. PubMed PMID: 27758891; PubMed Central PMCID: PMC5165695.

Onuchic V, Hartmaier RJ, Boone DN, Samuels ML, Patel RY, White WM, Garovic VD, Oesterreich S, Roth ME, Lee AV, Milosavljevic A. Epigenomic Deconvolution of  Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types. Cell Rep. 2016 Nov 15;17(8):2075-2086. doi: 10.1016/j.celrep.2016.10.057. PubMed PMID: 27851969; PubMed Central PMCID: PMC5115176.

Gyanchandani R, Lin Y, Lin HM, Cooper K, Normolle DP, Brufsky A, Fastuca M, Crosson W, Oesterreich S, Davidson NE, Bhargava R, Dabbs DJ, Lee AV. Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer. Clin Cancer Res. 2016 Nov 1;22(21):5362-5369. Epub 2016 May 16. PubMed PMID: 27185370; PubMed Central PMCID: PMC5093028.

Chandran UR, Medvedeva OP, Barmada MM, Blood PD, Chakka A, Luthra S, Ferreira A, Wong KF, Lee AV, Zhang Z, Budden R, Scott JR, Berndt A, Berg JM, Jacobson RS. TCGA Expedition: A Data Acquisition and Management System for TCGA Data. PLoS One. 2016 Oct 27;11(10):e0165395. doi: 10.1371/journal.pone.0165395. eCollection 2016. PubMed PMID: 27788220; PubMed Central PMCID: PMC5082933.

Farabaugh SM, Chan BT, Cui X, Dearth RK, Lee AV. Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer. Cell Commun Signal. 2016 Oct 21;14(1):25. PubMed PMID: 27765041; PubMed Central PMCID: PMC5073819.

Dennison JB, Shahmoradgoli M, Liu W, Ju Z, Meric-Bernstam F, Perou CM, Sahin  AA, Welm A, Oesterreich S, Sikora MJ, Brown RE, Mills GB. High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype. Clin Cancer Res. 2016 Oct 15;22(20):5068-5078. Epub 2016 May 12. PubMed PMID: 27172895; PubMed Central PMCID: PMC5103285.

Lee AV. The Endocrine Society Centennial: 40 Years of Aromatase Inhibitors as Targeted Therapy for Breast Cancer. Endocrinology. 2016 Oct;157(10):3697-3698. Epub 2016 Sep 6. PubMed PMID: 27599035.

Sikora MJ, Johnson MD, Lee AV, Oesterreich S. Endocrine Response Phenotypes Are Altered by Charcoal-Stripped Serum Variability. Endocrinology. 2016 Oct;157(10):3760-3766. Epub 2016 Jul 26. PubMed PMID: 27459541; PubMed Central PMCID: PMC5045515.

Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016 Sep 20;18(1):92. doi: 10.1186/s13058-016-0748-7. PubMed PMID: 27650553; PubMed Central PMCID: PMC5028957.

Gyanchandani R, Kota KJ, Jonnalagadda AR, Minteer T, Knapick BA, Oesterreich S, Brufsky AM, Lee AV, Puhalla SL. Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole. Oncotarget. 2016 Aug 19;8(40):66901-66911. doi: 10.18632/oncotarget.11383. eCollection 2017 Sep 15. PubMed PMID: 28978004; PubMed Central PMCID: PMC5620144.

Erdem C, Nagle AM, Casa AJ, Litzenburger BC, Wang YF, Taylor DL, Lee AV, Lezon TR. Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways. Mol Cell Proteomics. 2016 Sep;15(9):3045-57. doi: 10.1074/mcp.M115.057729. Epub 2016 Jun 30. PubMed PMID: 27364358; PubMed Central PMCID: PMC5013316.

Singh M, Mukundan S, Jaramillo M, Oesterreich S, Sant S. Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression. Cancer Res. 2016 Jul 1;76(13):3732-43. doi: 10.1158/0008-5472.CAN-15-2304. Epub 2016 May 23. PubMed PMID: 27216179; PubMed Central PMCID: PMC4947371.

Kim SH, Kaschula CH, Priedigkeit N, Lee AV, Singh SV. Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide. J Biol Chem. 2016 Jun 24;291(26):13495-508. doi: 10.1074/jbc.M116.715219. Epub 2016 Apr 29. PubMed PMID: 27129776; PubMed Central PMCID: PMC4919436.

Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol. 2016 May;141(2):348-356. doi: 10.1016/j.ygyno.2016.02.030. Epub 2016 Mar 11. PubMed PMID: 26946093; PubMed Central PMCID: PMC5154956.

Liu S, Tsai WH, Ding Y, Chen R, Fang Z, Huo Z, Kim S, Ma T, Chang TY, Priedigkeit NM, Lee AV, Luo J, Wang HW, Chung IF, Tseng GC. Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Res. 2016 Mar 18;44(5):e47. doi: 10.1093/nar/gkv1234. Epub 2015 Nov 17. PubMed PMID: 26582927; PubMed Central PMCID: PMC4797269.

Becker MA, Ibrahim YH, Oh AS, Fagan DH, Byron SA, Sarver AL, Lee AV, Shaw LM, Fan C, Perou CM, Yee D. Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer. PLoS One. 2016 Mar 18;11(3):e0150564. doi: 10.1371/journal.pone.0150564. eCollection 2016. PubMed PMID: 26991655; PubMed Central PMCID: PMC4798554.

Santa-Maria CA, Blackford A, Nguyen AT, Skaar TC, Philips S, Oesterreich S, Rae JM, Desta Z, Robarge J, Henry NL, Storniolo AM, Hayes DF, Blumenthal RS, Ouyang P, Post WS, Flockhart DA, Stearns V; Consortium on Breast Cancer Pharmacogenomics (COBRA). Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy. Clin Cancer Res. 2016 Mar 15;22(6):1395-402. doi: 10.1158/1078-0432.CCR-15-1213. Epub 2015 Oct 13. PubMed PMID: 26463708; PubMed Central PMCID: PMC4794377.

Jankowitz RC, Oesterreich S, Lee AV, Davidson NE. New Strategies in Metastatic Hormone Receptor-Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies. Clin Cancer Res. 2017 Mar 1;23(5):1126-1131. doi: 10.1158/1078-0432.CCR-16-0591. Epub 2016 Dec 15. PubMed PMID: 27979914; PubMed Central PMCID: PMC5350010.

Zhang M, Lee AV, Rosen JM. The Cellular Origin and Evolution of Breast Cancer. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3). pii: a027128. doi: 10.1101/cshperspect.a027128. Review. PubMed PMID: 28062556; PubMed Central PMCID: PMC5334246.

Wang P, Bahreini A, Gyanchandani R, Lucas PC, Hartmaier RJ, Watters RJ, Jonnalagadda AR, Trejo Bittar HE, Berg A, Hamilton RL, Kurland BF, Weiss KR, Mathew A, Leone JP, Davidson NE, Nikiforova MN, Brufsky AM, Ambros TF, Stern AM, Puhalla SL, Lee AV, Oesterreich S. Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients. Clin Cancer Res. 2016 Mar 1;22(5):1130-7. doi: 10.1158/1078-0432.CCR-15-1534. Epub 2015 Oct 23. PubMed PMID: 26500237; PubMed Central PMCID: PMC4775406.

Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE. THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. Epub 2017 Feb 13. PubMed PMID: 28193878; PubMed Central PMCID: PMC5338560.

Cao C, Vasilatos SN, Bhargava R, Fine JL, Oesterreich S, Davidson NE, Huang Y. Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression. Oncogene. 2017 Jan 5;36(1):133-145. doi: 10.1038/onc.2016.186. Epub 2016 May 23. PubMed PMID: 27212032; PubMed Central PMCID: PMC5121103.

Kim S, Oesterreich S, Kim S, Park Y, Tseng GC. Integrative clustering of multi-level omics data for disease subtype discovery using sequential double regularization. Biostatistics. 2017 Jan;18(1):165-179. doi: 10.1093/biostatistics/kxw039. Epub 2016 Aug 22. PubMed PMID: 27549122; PubMed Central PMCID: PMC5255053.

Boisen MM, Andersen CL, Sreekumar S, Stern AM, Oesterreich S. Treating gynecologic malignancies with selective estrogen receptor downregulators (SERDs): promise and challenges. Mol Cell Endocrinol. 2015 Dec 15;418 Pt 3:322-33. doi: 10.1016/j.mce.2015.04.035. Epub 2015 Aug 11. PubMed PMID: 26276546.

Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Dec;6(5-6):214-24. doi: 10.1007/s12672-015-0230-5. Epub 2015 Jun 26. PubMed PMID: 26113056; PubMed Central PMCID: PMC4807402.

Oesterreich S, Henry NL, Kidwell KM, Van Poznak CH, Skaar TC, Dantzer J, Li L, Hangartner TN, Peacock M, Nguyen AT, Rae JM, Desta Z, Philips S, Storniolo AM, Stearns V, Hayes DF, Flockhart DA. Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover. Breast Cancer Res Treat. 2015 Nov;154(2):263-73. doi: 10.1007/s10549-015-3608-8. Epub 2015 Nov 4. PubMed PMID: 26536870; PubMed Central PMCID: PMC4807610.

Casa AJ, Hochbaum D, Sreekumar S, Oesterreich S, Lee AV. The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor. Mol Cell Endocrinol. 2015 Nov 5;415:76-86. doi: 10.1016/j.mce.2015.08.007. Epub 2015 Aug 10. Erratum in: Mol Cell Endocrinol. 2016 Mar 15;424():129. PubMed PMID: 26272024.

Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Glymour C, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R; Center for Causal Discovery team. The center for causal discovery of biomedical knowledge from big data. J Am Med Inform Assoc. 2015 Nov;22(6):1132-6. doi: 10.1093/jamia/ocv059. Epub 2015 Jul 2. PubMed PMID: 26138794; PubMed Central PMCID: PMC5009908.

Leone JP, Bhargava R, Theisen BK, Hamilton RL, Lee AV, Brufsky AM. Expression of high affinity folate receptor in breast cancer brain metastasis. Oncotarget. 2015 Oct 6;6(30):30327-33. doi: 10.18632/oncotarget.4639. PubMed PMID: 26160847; PubMed Central PMCID: PMC4745802.

Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA; TCGA Research Network, Perou CM. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 2015 Oct 8;163(2):506-19. doi: 10.1016/j.cell.2015.09.033. PubMed PMID: 26451490; PubMed Central PMCID: PMC4603750.

Katz TA, Liao SG, Palmieri VJ, Dearth RK, Pathiraja TN, Huo Z, Shaw P, Small S, Davidson NE, Peters DG, Tseng GC, Oesterreich S, Lee AV. Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition. Cancer Prev Res (Phila). 2015 Oct;8(10):1000-9. doi: 10.1158/1940-6207.CAPR-15-0178. Epub 2015 Aug 19. PubMed PMID: 26290394; PubMed Central PMCID: PMC4677681.

Jiang S, Katz TA, Garee JP, DeMayo FJ, Lee AV, Oesterreich S. Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. Dis Model Mech. 2015 Sep;8(9):1121-7. doi: 10.1242/dmm.019885. Epub 2015 Jun 18. PubMed PMID: 26092125; PubMed Central PMCID: PMC4582101.

Brown DD, Dabbs DJ, Lee AV, McGuire KP, Ahrendt GM, Bhargava R, Davidson NE, Brufsky AM, Johnson RR, Oesterreich S, McAuliffe PF. Developing in vitro models of human ductal carcinoma in situ from primary tissue explants. Breast Cancer ResTreat. 2015 Sep;153(2):311-21. doi: 10.1007/s10549-015-3551-8. Epub 2015 Aug 18. PubMed PMID: 26283301.

Liao S, Hartmaier RJ, McGuire KP, Puhalla SL, Luthra S, Chandran UR, Ma T, Bhargava R, Modugno F, Davidson NE, Benz S, Lee AV, Tseng GC, Oesterreich S. The molecular landscape of premenopausal breast cancer. Breast Cancer Res. 2015 Aug 7;17:104. doi: 10.1186/s13058-015-0618-8. PubMed PMID: 26251034; PubMed Central PMCID: PMC4531812.

Leone JP, Lee AV, Brufsky AM. Prognostic factors and survival of patients with brain metastasis from breast cancer who underwent craniotomy. Cancer Med. 2015 Jul;4(7):989-94. doi: 10.1002/cam4.439. Epub 2015 Mar 9. PubMed PMID: 25756607; PubMed Central PMCID: PMC4529337.

Logan GJ, Dabbs DJ, Lucas PC, Jankowitz RC, Brown DD, Clark BZ, Oesterreich S, McAuliffe PF. Molecular drivers of lobular carcinoma in situ. Breast Cancer Res. 2015 Jun 4;17:76. doi: 10.1186/s13058-015-0580-5. Review. PubMed PMID: 26041550; PubMed Central PMCID: PMC4453073.

Reeder A, Attar M, Nazario L, Bathula C, Zhang A, Hochbaum D, Roy E, Cooper KL, Oesterreich S, Davidson NE, Neumann CA, Flint MS. Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage. Br J Cancer. 2015 Apr 28;112(9):1461-70. doi: 10.1038/bjc.2015.133. Epub 2015 Apr 16. PubMed PMID: 25880007; PubMed Central PMCID: PMC4453678.

Farabaugh SM, Boone DN, Lee AV. Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation. Front Endocrinol (Lausanne). 2015 Apr 24;6:59. doi: 10.3389/fendo.2015.00059. eCollection 2015. Review. PubMed PMID: 25964777; PubMed Central PMCID: PMC4408912.

Lee AV, Oesterreich S, Davidson NE. MCF-7 cells–changing the course of breast cancer research and care for 45 years. J Natl Cancer Inst. 2015 Mar 31;107(7). pii: djv073. doi: 10.1093/jnci/djv073. Print 2015 Jul. PubMed PMID: 25828948.

Wang P, Bahreini A, Gyanchandani R, Lucas PC, Hartmaier RJ, Watters RJ, Jonnalagadda AR, Trejo Bittar HE, Berg A, Hamilton RL, Kurland BF, Weiss KR, Mathew A, Leone JP, Davidson NE, Nikiforova MN, Brufsky AM, Ambros TF, Stern AM, Puhalla SL, Lee AV, Oesterreich S. Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients. Clin Cancer Res. 2016 Mar 1;22(5):1130-7. doi: 10.1158/1078-0432.CCR-15-1534. Epub 2015 Oct 23. PubMed PMID: 26500237; PubMed Central PMCID: PMC4775406.

Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S. Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer. Sci Transl Med. 2014 Mar 26;6(229):229ra41. doi: 10.1126/scitranslmed.3008326. PubMed PMID: 24670685; PubMed Central PMCID: PMC4277862.

Ding Y, Tang S, Liao SG, Jia J, Oesterreich S, Lin Y, Tseng GC. Bias correction for selecting the minimal-error classifier from many machine learning models. Bioinformatics. 2014 Nov 15;30(22):3152-8. doi: 10.1093/bioinformatics/btu520. Epub 2014 Aug 1. PubMed PMID: 25086004; PubMed Central PMCID: PMC4221122.

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL. Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. PLoS One. 2014 Jul 18;9(7):e102678. doi: 10.1371/journal.pone.0102678. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0120468. PubMed PMID: 25036749; PubMed Central PMCID: PMC4103836.

Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. Breast Cancer Res Treat. 2014 Jul;146(1):99-108. doi: 10.1007/s10549-014-3012-9. Epub 2014 Jun 13. PubMed PMID: 24924415.

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al. Front Neuroendocrinol. 2014 Jan;35(1):2-5. doi: 10.1016/j.yfrne.2013.09.003. Epub 2013 Nov 21. PubMed PMID: 24268499.

Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O’Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S. A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol. 2012 Feb;26(2):220-7. doi: 10.1210/me.2011-1032. Epub 2011 Dec 15. PubMed PMID: 22174377; PubMed Central PMCID: PMC3275159.

Casa AJ, Potter AS, Malik S, Lazard Z, Kuiatse I, Kim HT, Tsimelzon A, Creighton CJ, Hilsenbeck SG, Brown PH, Oesterreich S, Lee AV. Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth. Breast Cancer Res Treat. 2012 Feb;132(1):61-73. doi: 10.1007/s10549-011-1540-0. Epub 2011 May 4. PubMed PMID: 21541704; PubMed Central PMCID: PMC3936881.

Oesterreich S, Lee AV, Davidson NE. Is it time to ReSET the standard for estrogen receptor testing in breast cancer? J Clin Oncol. 2010 Sep 20;28(27):4101-3. doi: 10.1200/JCO.2010.30.9864. Epub 2010 Aug 9. PubMed PMID: 20697070.

Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterreich S, Medina D, Dees WL, Lee AV. Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer. Cancer Prev Res (Phila). 2010 Mar;3(3):312-21. doi: 10.1158/1940-6207.CAPR-09-0074. Epub 2010 Feb 9. PubMed PMID: 20145191; PubMed Central PMCID: PMC2833223.

Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O’Malley BW, Zhang M, Belaguli NS, Oesterreich S. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Mol Cell Biol. 2010 Jan;30(2):399-412. doi: 10.1128/MCB.00907-09. Epub 2009 Nov 16. PubMed PMID: 19917725; PubMed Central PMCID: PMC2798473.

Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold Attachment Factor B1 (SAFB1) heterozygositydoes not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer. 2009 Mar 6;8:15. doi: 10.1186/1476-4598-8-15. PubMed PMID: 19267898; PubMed Central PMCID: PMC2669049.

Kaipparettu BA, Kuiatse I, Tak-Yee Chan B, Benny Kaipparettu M, Lee AV, Oesterreich S. Novel egg white-based 3-D cell culture system. Biotechniques. 2008 Aug;45(2):165-8, 170-1. doi: 10.2144/000112883. PubMed PMID: 18687065.

Townson SM, Kang K, Lee AV, Oesterreich S. Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells. Biochem Biophys Res Commun. 2006 Oct 20;349(2):540-8. Epub 2006 Aug 22. PubMed PMID: 16945332; PubMed Central PMCID: PMC1950156.

Dobrzycka KM, Kang K, Jiang S, Meyer R, Rao PH, Lee AV, Oesterreich S. Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalization. Cancer Res. 2006 Aug 15;66(16):7859-63. PubMed PMID: 16912158.

Ivanova M, Dobrzycka KM, Jiang S, Michaelis K, Meyer R, Kang K, Adkins B, Barski OA, Zubairy S, Divisova J, Lee AV, Oesterreich S. Scaffold attachment factor B1 functions in development, growth, and reproduction. Mol Cell Biol. 2005 Apr;25(8):2995-3006. PubMed PMID: 15798188; PubMed Central PMCID: PMC1069606.

Townson SM, Kang K, Lee AV, Oesterreich S. Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain. J Biol Chem. 2004 Jun 18;279(25):26074-81. Epub 2004 Apr 5. PubMed PMID: 15066997.

Lee AV, Chamness G, Oesterreich S. 26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3-6 December 2003: update on preclinical and translational research. Breast Cancer Res. 2004 Jan 19;6(2):E10. PubMed PMID: 14979916; PubMed Central PMCID: PMC400657.

Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Behrens J, Lee AV. Estrogen-mediated down-regulation of E-cadherin in breast cancer cells. Cancer Res. 2003 Sep 1;63(17):5203-8. PubMed PMID: 14500345.

Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL. Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Endocrinology. 2003 Jun;144(6):2683-94. PubMed PMID: 12746333.

Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. J Biol Chem. 2003 May 30;278(22):20059-68. Epub 2003 Mar 26. PubMed PMID: 12660241.

Cui X, Zhang P, Deng W, Oesterreich S, Lu Y, Mills GB, Lee AV. Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer. Mol Endocrinol. 2003 Apr;17(4):575-88. Epub 2003 Jan 2. Erratum in: Mol Endocrinol. 2003 Sep;17(9):1892. PubMed PMID: 12554765.

Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL. New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation. Clin Cancer Res. 2003 Jan;9(1 Pt 2):516S-23S. Review. PubMed PMID: 12538509.

Lee AV, Cui X, Oesterreich S. Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clin Cancer Res. 2001 Dec;7(12 Suppl):4429s-4435s; discussion 4411s-4412s. Review. PubMed PMID: 11916236.

Oesterreich S, Zhang P, Guler RL, Sun X, Curran EM, Welshons WV, Osborne CK, Lee AV. Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Res. 2001 Aug 1;61(15):5771-7. PubMed PMID: 11479214.

Oesterreich S, Allredl DC, Mohsin SK, Zhang Q, Wong H, Lee AV, Osborne CK, O’Connell P. High rates of loss of heterozygosity on chromosome 19p13 in human breast cancer. Br J Cancer. 2001 Feb;84(4):493-8. PubMed PMID: 11207044; PubMed Central PMCID: PMC2363776.

Oesterreich S, Zhang QP, Lee AV. Inhibition of oestrogen receptor activity by the co-repressor HET/SAF-B is relieved by blockade of histone deacetylase activity. Eur J Cancer. 2000 Sep;36 Suppl 4:S43-4. PubMed PMID: 11056314.

Lee AV, Guler BL, Sun X, Oesterreich S, Zhang QP, Curran EM, Welshons WV. Oestrogen receptor is a critical component required for insulin-like growth factor (IGF)-mediated signalling and growth in MCF-7 cells. Eur J Cancer. 2000 Sep;36 Suppl 4:109-10. PubMed PMID: 11056354.

Townson SM, Sullivan T, Zhang Q, Clark GM, Osborne CK, Lee AV, Oesterreich S. HET/SAF-B overexpression causes growth arrest and multinuclearity and is associated with aneuploidy in human breast cancer. Clin Cancer Res. 2000 Sep;6(9):3788-96. PubMed PMID: 10999774.

Oesterreich S, Zhang Q, Hopp T, Fuqua SA, Michaelis M, Zhao HH, Davie JR, Osborne CK, Lee AV. Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation. Mol Endocrinol. 2000 Mar;14(3):369-81. PubMed PMID: 10707955.

Lee AV, Gooch JL, Oesterreich S, Guler RL, Yee D. Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3′-kinase inhibition. Mol Cell Biol. 2000 Mar;20(5):1489-96. PubMed PMID: 10669726; PubMed Central PMCID: PMC85315.