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Our paper about ESR1 mutations and breast cancer metastasis is now published in Cancer Research! 

https://cancerres.aacrjournals.org/content/early/2022/01/25/0008-5472.CAN-21-2576
Zheqi (Vaciry) Li, Ph.D.

This study was led by former graduate student Vaciry Li with great efforts from many intra- and inter-group collaborations. Congratulations to all! 

In this study, we showed that context and allele-dependent transcriptome and cistrome reprogramming in ESR1 mutation cell models, which elicit diverse metastatic phenotypes related to cell-cell adhesion, cell-ECM adhesion and migration driven by increased desmosome/gap junctions, dampened TIMP3-MMP axis and Wnt pathway. Importantly, some of these pathways can pharmacologically targeted and reveals novel therapeutic strategies.  

The Lee/Oesterreich lab receives two Breast Cancer Alliance Exceptional Project Grants!

The Lee/Oesterreich lab is delighted to receive two grant awards from the Breast Cancer Alliance (http://breastcanceralliance.org/).

The BCA selected to fund our projects entitled ‘Therapeutic targeting of novel pathways in breast cancer brain metastases’ and ‘Understanding the importance of ESR1 fusion genes in metastatic breast cancer”. The grants provide one year of funding support for these exciting projects.

We are very grateful for the funding to continue our quest to better understand and target endocrine resistant breast cancer.