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Our EstroGene browser is launched to the public!

We are pleased to introduce the EstroGene Project -a comprehensive multi-omic NGS database focusing on estrogen receptor function in breast cancer. It aims to document and integrate the majority of publicly available estrogen-stimulated next generation sequencing data sets (including RNA-seq, microarray, ChIP-seq, ATAC-seq, ChIA-PET, Hi-C, GRO-seq, etc), and establish a comprehensive database to allow users’ customized data mining and visualization. We have curated 136 published NGS data sets from 2004-2022 across 19 breast cancer cell lines and generated a browser for simplified queries.

Features of EstroGene:

-A uniformly processed and crowd-sourced multi-omic database with detailed experimental documentation summary.

-A browser allowing single gene-based visualization of E2-induced expressional changes and ER proximal binding at users’ selected genes of interest.

-A browser supporting statistical cutoff-based gene list query function to export genes regulated by E2 under users’ defined contexts.

-An ER and breast cancer-centered database for dissecting the biological and technical diversity and variation of estrogen receptor-relevant NGS experiments and the confound ER regulomes in breast cancer.

We have summarized all of the curated datasets in this google form. We are crowd-sourcing additional datasets that may not be available in the public domain but are available within laboratories. If you have such a dataset please don’t hesitate to fill in the google form and we will contact you back.

We would appreciate it if you could operate the website and give us feedbacks to improve it and continue notify us about new data sets via the google form.

The BioRxiv manuscript of this project will be deposit after receiving feedbacks from the research community!

For any queries please email Nadine Ryan (

Our paper about ESR1 mutations and breast cancer metastasis is now published in Cancer Research!
Zheqi (Vaciry) Li, Ph.D.

This study was led by former graduate student Vaciry Li with great efforts from many intra- and inter-group collaborations. Congratulations to all! 

In this study, we showed that context and allele-dependent transcriptome and cistrome reprogramming in ESR1 mutation cell models, which elicit diverse metastatic phenotypes related to cell-cell adhesion, cell-ECM adhesion and migration driven by increased desmosome/gap junctions, dampened TIMP3-MMP axis and Wnt pathway. Importantly, some of these pathways can pharmacologically targeted and reveals novel therapeutic strategies.  

Our new review is out now in The Lancet Healthy Longevity!

Led by PhD student Neil Carleton and senior authors Adrian Lee, Priscilla McAuliffe, and Steffi Oesterreich, we review key considerations for “right-sizing” therapy options for older women with ER+ breast cancer. With contributions from radiation, pathology, surgical oncology, radiation oncology, and medical oncology from the UPMC / Magee Women’s Hospital breast cancer group, this collaborative effort touches on optimizing quality of life along with new translational studies that may impact future treatment of these patients. 

Check it out at: