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Our paper about ESR1 mutations and breast cancer metastasis is now published in Cancer Research! 

https://cancerres.aacrjournals.org/content/early/2022/01/25/0008-5472.CAN-21-2576
Zheqi (Vaciry) Li, Ph.D.

This study was led by former graduate student Vaciry Li with great efforts from many intra- and inter-group collaborations. Congratulations to all! 

In this study, we showed that context and allele-dependent transcriptome and cistrome reprogramming in ESR1 mutation cell models, which elicit diverse metastatic phenotypes related to cell-cell adhesion, cell-ECM adhesion and migration driven by increased desmosome/gap junctions, dampened TIMP3-MMP axis and Wnt pathway. Importantly, some of these pathways can pharmacologically targeted and reveals novel therapeutic strategies.  

Our new review is out now in The Lancet Healthy Longevity!

Led by PhD student Neil Carleton and senior authors Adrian Lee, Priscilla McAuliffe, and Steffi Oesterreich, we review key considerations for “right-sizing” therapy options for older women with ER+ breast cancer. With contributions from radiation, pathology, surgical oncology, radiation oncology, and medical oncology from the UPMC / Magee Women’s Hospital breast cancer group, this collaborative effort touches on optimizing quality of life along with new translational studies that may impact future treatment of these patients. 

Check it out at: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00280-4/fulltext.