Limited availability of research models was a substantial barrier that at least partially accounted for the lack of research on ILC. Dr. Nilgun Tasdemir, a postdoc in the lab, performed a very elegant and thorough characterization of ILC cell lines – the start of our commitment to generate more ILC models faithfully representing different aspects of the disease. This project, with bioinformatics support from George Tseng, characterized 2D and 3D growth phenotypes of ILC cell lines. It emphasized how the unique morphology and cell–cell adhesion defects influence drug response and invasion, building a phenotypic framework for preclinical modeling.
Important ILC Research: “Comprehensive 2D and 3D phenotypic characterization of human invasive lobular carcinoma cell lines”
