Dr. Rohit Bhargava and his team identified a distinct breast cancer type called “lobular-like invasive mammary carcinomas” (LLIMCas) that resembles lobular cancers histologically but lacks their characteristic CDH1 gene mutations, instead showing CDH1 promoter methylation. LLIMCas are often underestimated on imaging with frequent positive margins, and thus Dr. Bhargava recommends recognizing them as a separate entity and using preoperative MRI to guide surgical management.
Important ILC Research: “Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?”
