Dr. Oesterreich was honored and excited to join The Cancer Genome Atlas Network (TCGA) working group performing the largest to date comprehensive molecular analysis of ILC. This landmark paper provided a comprehensive molecular portrait of ILC, highlighting distinct genomic and transcriptomic features compared to invasive ductal carcinoma (IDC). Dr. Oesterreich contributed key expertise in lobular biology, ensuring that ILC was well represented within TCGA analyses, reflecting a major collaborative effort among over 50 institutions. The study showed that 95% of ILC cases had alterations in CDH1, that there were differences in mutations frequency (for example in PTEN, AKT, FOXA1 and TBX3), and that there are molecular variants within ILC. The conclusion was that “ILC is a clinically and molecularly distinct disease”.
Important ILC Research: “Comprehensive molecular portraits of invasive lobular breast cancer”
