This truly multi-disciplinary study with experts in immunology, bioinformatics, pathology and ILC allowed us to show that there were differences in immune infiltration between ER+ ILC and ER+ NST. While majority of ILC were “cold”, some were infiltrated with immune cells, dominated by M2-like macrophages. Spatial analyses identified neighborhoods with different prognosis in ILC vs NST.
Important ILC Research: “Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment”
