This foundational study established that invasive lobular carcinoma (ILC) cell lines exhibit unique estrogen-mediated transcriptional programs and distinct tamoxifen responses compared to ductal models. Led by Dr. Matthew Sikora during his postdoctoral training in the Oesterreich–Lee laboratory, the work included collaborations with multiple Pitt faculty and collaborators such as Dr. Alana Welm (Utah), providing the first systematic evidence for differential estrogen signaling in ILC. Dr. Sikora is now Associate Professor at UC and is continuing work on ILC.
Important ILC Research: “Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response.”
