Important ILC Research: “Is the Choosing Wisely Recommendation for Omission of Sentinel Lymph Node Biopsy Applicable for Invasive Lobular Carcinoma?”

In older women (≥70) with early-stage ER+ invasive lobular carcinoma (ILC), omitting sentinel lymph node biopsy (SLNB) was not associated with increased recurrence or worse locoregional recurrence-free survival compared to those who underwent SLNB, even though ILC patients presented with larger, higher-stage tumors. These findings support extending the Choosing Wisely recommendation to omit SLNB to patients with ILC, though larger studies and ongoing trials (SOUND, INSEMA) are needed to validate this conclusion.