In a collaboration with the NSABP, we studied many clinico-pathological features of a large series of mixed ductal lobular cancer, and concluded that mixed IDC/ILC were more similar to ILC than IDC/NST. It is important to note that the WHO definition of mixed IDC/ILC has recently changed – the proportion of the special subtype in mixed tumors has decreased from 50% to 10%. It will be challenging to apply conclusions from our study to mixed cases with different definitions. These changes not only reflect the complicated nature of the mixed IDC/ILC tumors, but also the ever-changing definition. It is likely that the use of AI will help to clarify different ILC subtypes, including the mixed IDC/ILC cases.
Important ILC Research: “Mixed invasive ductal lobular carcinoma is clinically and pathologically more similar to invasive lobular than ductal carcinoma”
