It remains challenging to understand and categorize mixed ductal lobular tumors. In this study, we utilized spatially resolved transcriptomic, genomic, and single-cell profiling for a comprehensive characterization of three mixed cases (categorized as such by three expert breast cancer pathologists at UPMC, UM and MSKCC). We identified clinically significant differences between ductal and lobular tumor regions including distinct intrinsic subtype heterogeneity – a finding that indicates challenges for prognosis and therapeutic decisions for these cases.
Important ILC Research: “Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations”
