This study was led by former graduate student Vaciry Li with great efforts from many intra- and inter-group collaborations. Congratulations to all!
In this study, we showed that context and allele-dependent transcriptome and cistrome reprogramming in ESR1 mutation cell models, which elicit diverse metastatic phenotypes related to cell-cell adhesion, cell-ECM adhesion and migration driven by increased desmosome/gap junctions, dampened TIMP3-MMP axis and Wnt pathway. Importantly, some of these pathways can pharmacologically targeted and reveals novel therapeutic strategies.
Our paper is out on ESTROGEN RECEPTOR MUTATIONS – so much more than endocrine resistance. Multiple roles in #metastaticbreastcancer Great work by @ZheqiL @UPMCHillmanCC @MageeWomens now postdoc @DanaFarber @Adrianvlee https://t.co/X1baEXelai pic.twitter.com/nI7VNbrzau— Dr. Steffi Oesterreich (@oesterreichs) January 27, 2022