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New Publication! “Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors”

Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors

We provide evidence that loss of E-cadherin hyperactivates the IGF1R pathway and increases sensitivity to IGF1R/InsR targeted therapy, thus identifying the IGF1R pathway as a potential novel target in E-cadherin–deficient breast cancers such as invasive lobular cancer.

Drs. Adrian Lee and Steffi Oesterreich received the 2018 PNC Elsie Hillman Distinguished Scholar Award!

Congratulations to Drs. Adrian Lee and Steffi Oesterreich on receiving the 2018 PNC Elsie Hillman Distinguished Scholar Award.  The award was announced at this year’s UPMC Hillman Gala that took place on Thursday, September 20 at PPG Paints Arena. Drs. Lee and Oesterreich were joined on that special evening by their daughters Paula and Nicola Lee-Oesterreich (photo below). You can read further coverage at the Pittsburgh-Post Gazette.

Photos from the gala:

Adrian and Steffi with Lou Cestello, Regional President, PNC
With Paula and Nicola Lee-Oesterreich
The award!

  

 

New publication! “Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer”

Our latest paper focused on lobular breast cancer is now available. Role for SREBP1 and other regulators of fatty acid and cholesterol synthesis in invasive lobular breast cancer.