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The Lee/Oesterreich lab receives two Breast Cancer Alliance Exceptional Project Grants!

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The Lee/Oesterreich lab is delighted to receive two grant awards from the Breast Cancer Alliance (http://breastcanceralliance.org/).

The BCA selected to fund our projects entitled ‘Therapeutic targeting of novel pathways in breast cancer brain metastases’ and ‘Understanding the importance of ESR1 fusion genes in metastatic breast cancer”. The grants provide one year of funding support for these exciting projects.

We are very grateful for the funding to continue our quest to better understand and target endocrine resistant breast cancer.

Dr. Adrian Lee interviewed on the “Do-Goodery Podcast: The Cancer Episode”!

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Dr. Adrian Lee was recently interviewed for the “Do-Goodery Podcast: The Cancer Episode” to, as described by their website, “discuss what a jerk Cancer is. We Take Astro 101, learn about new weapons in the fight against Cancer, and how to support those who’ve received a Cancer diagnosis.”

Listen here:

 

Dr. Oesterreich discusses ILC at NWMBCC in Seattle

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Steffi meets with members of LBCA advocacy group (https://lobularbreastcancer.org/), and discusses progress and challenges for ILC research at the Northwest Metastatic Breast Cancer Conference (NWMBCC).

The presentation was live streamed, and can be seen here: https://www.facebook.com/lobularbreastcanceralliance/videos/553742191751845/.

Of note, Leigh Pate, founder of LBCA, receives the Beth Caldwell Breakthrough Leadership award.

New Publication! “Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors”

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Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors

We provide evidence that loss of E-cadherin hyperactivates the IGF1R pathway and increases sensitivity to IGF1R/InsR targeted therapy, thus identifying the IGF1R pathway as a potential novel target in E-cadherin–deficient breast cancers such as invasive lobular cancer.

New publication! “Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer”

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Our latest paper focused on lobular breast cancer is now available. Role for SREBP1 and other regulators of fatty acid and cholesterol synthesis in invasive lobular breast cancer.